Contrasting roles of interallelic recombination at the HLA-A and HLA-B locus

Article Abstract:

The rates of intralocus recombination were quantified by statistical analysis of DNA sequences of human HLA-A and HLA-B class I MHC loci. Recombination occurred twice as frequently at the B locus than the A locus with B locus recombinants significantly affecting polymorphic sites in the antigen recognition sites. Well-defined allelic lineages in the A locus seem to have persisted prior to the human-chimpanzee divergence in contrast to the B locus. Thus, relatively frequent interallelic recombination has been a feature of long-term evolution of the B locus.

Genetic aspects, HLA histocompatibility antigens, HLA antigens, Major histocompatibility complex

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Hot spots of recombination in fission yeast: inactivation of the M26 hot spot by deletion of the ade6 promoter and the novel hotspot ura4-aim

Article Abstract:

The M26 mutation is widely recognized as a meiotic recombination hot spot in Schizosaccharomyces pombe. The hot spot, also a single base substitution, is located within the ade6 open reading frame near the 5' end. Although M26 accounts for both homologous and ectopic recombination in meiosis, it fails to catalyze mitotic recombination. An active M26 decreases activity for the ura4-aim novel recombination hot spot.

Mutation (Biology), Mutation

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