Induction of the sexual stage of Pestalotiopsis microspora, a taxol-producing fungus
Article Abstract:
Results demonstrate that a teleomorph stage in Pestalotiopsis microspora fungus is optimum for the production of taxol used in the cancer therapy. Data suggest that the teleomorphs are induced by certain hydrophobic compounds of the host plants.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2000
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Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana
Article Abstract:
An isolate of the endophytic fungus Pestalotiopsis microspora obtained from the inner bark of Taxus wallachiana was observed to produce taxol in culture. In addition, the isolated taxol is found to be biologically active against certain cancer cell lines. The taxol is also spectroscopically identical to real taxol. It accumulates in cultures at the level of micrograms per liter. Results show that P. microspora deserves to be the subject of future research efforts in fermentation technology.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
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Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina
Article Abstract:
Cryptocandin, a unique lipopeptide antimycotic, has been derived the endophytic fungus Cryptosporiopsis cf. quercina. Cryptocandin, which has a molecular mass of 1079 Da, exhibits minimal inhibitory concentration values of 0.03 to 0.07 microgram/ml against isolates of Trichophyton mentagrophytes, Trichophyton rubrum and Candida albicans. Cryptocandin has also been demonstrated to be active against plant-pathogenic fungi such as Botrytis cinerea and Sclerotinia sclerotiorum.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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