Deconstructing the cadherin-catenin-actin complex

Article Abstract:

The organization of spatial and functional cells in tissues is determined by cell-cell adhesion proteins that play an important role in imitating adhesion and cell sorting development. The regulation of cadherin-mediated cell-cell adhesion is determined by a set of protein interactions of the cadherin extracellular and cytoplasmic domains.

Science & research, Research, Cell adhesion, Protein research

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Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding

Article Abstract:

Structural analysis of the yeast Cue2 protein CUE domain in complex with ubiquitin shows intermolecular interactions involving hydrophobic surfaces and a patch on the ubiquitin surface, suggesting that the complex may function as a paradigm for ubiquitin recognition and signalling by ubiquitin binding proteins.

Cellular signal transduction, Ubiquitin, Structure

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The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin

Article Abstract:

Three-dimensional structure of E-cadherin cytoplasmic domains complexed with beta-catenin reveals that beta-catenin binds its various partners on to the same surface. In the phosphorylated state, E-cadherin interacts with a hydrophobic patch of beta-catenin.

Statistical Data Included, Cell adhesion molecules, Binding sites (Biochemistry), Active sites (Biochemistry)

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