Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(super.x) and PSGL-1

Article Abstract:

The crystal structure of P-selectin LE co-complexed with the N-terminal of human PSGL-1 modified by both tyrosine sulfation and SLe(super.x) has been determined. Differences in the ways in which E- and P-selectin bind SLe(super.x) have been found and the molecular basis of the high-affinity interaction between Pselectin and PSGL-1 investigated. Selectins are cell-surface glycoproteins responsible for early adhesion events in the recruiting leukocytes into inflammation sites and for leukocyte emigration into lymph tissue.

Glycoproteins, Inflammation, Cell adhesion, Leukocytes, White blood cells

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MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

Article Abstract:

Mice deficient in a membrane-bound matrix metalloproteinase, MT1-MMP, and the defects they develop as a result of having inadequate collagen turnover are discussed. They have connective tissue disease, osteopenia, dwarfism, and arthritis. MT1-MMP is a membrane-bound matrix metalloproteinase (MT-MMP) that can mediate pericellular proteolysis of extracellular matrix components. MT1-MMP has a pivotal function in connective tissue metabolism.

Italy, Canada, Statistical Data Included, Usage, Arthritis, Mice, mutant strains, Mutant mice, Dwarfism, Connective tissue cells

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Structural basis of collagen recognition by integrin (alpha)2(beta)1

Article Abstract:

The structural basis of collagen recognition by integrin (alpha)2(beta)1 is discussed. The crystal structure of a complex between the I domain of integrin (alpha)2(beta)1 and a triple helical collagen peptide with a critical FGOGER motif has been found. Structural features may show a mechanism for integrin-ligand recognition in general.

United Kingdom, Crystals, Crystal structure, Cytogenetics

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