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A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Article Abstract:

Research has been conducted on the TRAF proteins. The structure of the TRADD-TRAF2 complex has been investigated.

Author: Park, Young Chul, Ye, Hong, Hsai, Constance, Segal, Deena, Rich, Rebecca L., Liou, Hsiou-Chi, Myszka, David G., Wu, Hao
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Statistical Data Included, Genetic transcription, Transcription (Genetics)

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Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

Article Abstract:

Research has been conducted on the inhibitor of apoptosis proteins (IAPs) which are characterized by the presence of the baculoviral inhibitor of apoptosis repeats (BIRs). The crystal structure of the complex between the human caspase-7 and XIAP (BIR2 and the proceeding linker) has been investigated and the results indicate that the linker is the only contacting element for the caspase and BIR2 domain is invisible in the crystal.

Author: Park, Young Chul, Segal, Deena, Rich, Rebecca L., Myszka, David G., Wu, Hao, Huang, Yihua
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Physiological aspects, Baculoviruses

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Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

Article Abstract:

Results show that HIV-1 budding requires a vacuolar protein sorting pathway protein, Tsg101. It binds to a tetrapeptide motif of the Gag protein P6 domain and to ubiquitin.

Author: Rich, Rebecca L., Myszka, David G., Sundquist, Wesley I., Garrus, Jennifer E., Schwedler, Uta K. von, Pornillos, Owen W., Morham, Scott G., Zavitz, Kenton H., Wang, Hubert E., Wettstein, Daniel A., Stray, Kristen M., Cote, Melanie
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
HIV (Viruses), HIV, Genetic aspects, Retroviruses, Virus replication, Budding, Grafting (Horticulture)

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Subjects list: Research, United States, Analysis, Cell death, Proteins, Cell research, Cytological research
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