Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration
Article Abstract:
Research has been conducted on cell migration. The author reviews the articles that discuss molecular pathways coordinating cell motility and development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament
Article Abstract:
The actin-driven migration of neuronal growth cones during axonal development is regulated by the murine protein, Mena, which exhibits a similar structure to the vasodilator-stimulated phosphoprotein. Mena promotes actin polymerization during axogenesis and induce the formation of F-actin-rich outgrowths in the fibroblasts. The actin-rich outgrowths the are produced by Mena reorganize actin polymerization for cell migration during axogenesis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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