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Transcriptional healing

Article Abstract:

Research has been conducted on DNA chemical structure. The effects of DNA injury on transcription machinery have been investigated.

Author: Citterio, Elisabetta, Vermeulen, Wim, Hoeijmakers, Jan H.J.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
Netherlands, Statistical Data Included, Analysis, Cell research, Cytological research

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DNA damage triggers nucleotide excision repair-dependent monobiquitylation of histone H2A

Article Abstract:

Chromatin changes within the context of DNA repair remain obscure, however, it is shown that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet (UV)- exposure of human cells causes a significant nucleotide excision repair (NER)-dependent monoubiquitylation of H2A and occurs after the incision of the damaged strand and this forms part of the cellular response to UV damage and suggests a role of this modification in DNA repair-induced chromatin modeling.

Author: Neefjes, Jacques, Citterio, Elisabetta, Vermeulen, Wim, Hoeijmakers, Jan H.J., Bergink, Steven, Li Yuan, Salomons, Florian A., Hoogstraten, Deborah, Dantama, Nico P., Groothuis, Tom A.M., Houtsmuller, Adriaan B., de Waard, Harm, Junxin Wu
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
Science & research, Histones

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Defective transcription-coupled repair in cockayne syndrome b mice is associated with skin cancer predisposition

Article Abstract:

The correlation between defective transcription-coupled repair in nucleotide excision repair disorder Cockayne syndrome B (CSB) and skin cancer susceptibility was analyzed by using a mouse model which mimicked a truncation in the CSB(ERCC6) gene of a CSB human patient thus, rendering it transcription-coupled repair deficient also. Both TCR deficient humans and mice expressed photosensitivity. Mice have a higher risk of skin cancer due to a weak global genome repair system, in contrast to humans who have reportedly lower risk due to a more potent global genome repair system.

Author: Hoeijmakers, Jan H.J., Steeg, Harry van, Wit, Jan de, Beems, Rudolph B., Berg, Rob J.W., Bootsma, Dirk, Gool, Alain J., van, Gruijl, Frank R., de, Horst, Gijsbertus T.J., van der, Kreijl, Coen F., van, Morreau, Hans, Weeda, Geert
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
Gene mutations, Gene mutation, Genetic aspects, Cells (Biology), Cells, Skin cancer, Radiation effects

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Subjects list: Research, DNA repair, DNA damage, Genetic transcription, Transcription (Genetics)
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