Differential effects of PER2 phosphorylation: Molecular basis for the human familial advanced sleep phase syndrome (FASPS)

Article Abstract:

Mathematical modeling is used to predict that differential PERIOD (PER) phosphorylation events can result in opposite period phenotypes. The interference with specific aspects of mPER2 phosphorylation leads to either short or long periods in oscillating fibroblasts and this concept describes not only the familial advanced sleep phase syndrome phenotype, but also the effect of the tau mutation in hamster as well as the doubletime mutants in Drosophila.

Germany, Circadian rhythms

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Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis

Article Abstract:

A demonstration that the histone H4 Ser1 is phosphorylated (H4 S1ph) during sporulation, starting from the mid-sporulation and persisting to germination, and is temporally distinct from earlier meiosis-linked H3 S10ph involved in chromosome condensation is presented. S1ph is found to be present during Drosphilia melangaster and mouse spermatogenesis, and similar to yeast, this modification extends late into sperm differentiation relative to H3 S10ph.

Maryland, Sexual behavior, Yeast fungi, Yeasts (Fungi), Spermatogenesis

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The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons

Article Abstract:

A study was undertaken to observe the requirement for Phr1 in CNS axon tract formation. Results revealed that in the nervous system of mammals Phr1 was important for formation of major CNS axon tracts through a mechanism that was cell-autonomous and independent of dual leucine zipper kinase.

Polymerase chain reaction, Axons, Neural transmission, Synaptic transmission

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