Dimerization of cell surface receptors in signal transduction

Article Abstract:

Studies of intracellular signal transduction pathways indicate that dimerization modulates the activities of many components of the transduction pathways. Oligomerization or dimerization occurs following the association of cytokines, growth factors, polypeptide hormones or growth inhibitors with their receptors and prior to receptor autophosphorylation on a conserved tyrosine residue inside or outside the kinase domains. Homodimeric complex formation between two catalytically active subunits or heterodimeric complex formation between one inactive and one active subunit results from the dimerization of kinase receptors after ligand binding.

Analysis, Cellular signal transduction, Cell receptors

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Initial axial level-dependent differences in size of avian dorsal root ganglia are imposed by the sclerotome

Article Abstract:

Immunocytochemical studies and analysis of segmental plate mesoderm grafts from cervical and brachial levels and vice versa confirm that the asymmetry in avian dorsal root ganglia (DRG) size during gangliogenesis is due to the presence of excessive paraxial mesoderm and enhanced DRG growth at brachial levels. The mesodermal microenvironment of DRG at the two axial levels causes variations in the number of cells at each level.

Growth, Mesoderm, Ganglia

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