Distinctions between c-Rel and other NF-kB proteins in immunity and disease

Article Abstract:

A proto-oncogene c-Rel, previously identified as a cellular counterpart of the v-Rel oncogene, belongs to the NF-KB/Rel factor family that share common DNA recognition and similar pathways. The study of c-Rel knockout mice in several disease model will be discussed for revealing an important role in response to allergens, auto-antigens, allo-antigens and pathogenic infection.

C-reactive protein, Oncogenes

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Repair of exocyclic DNA adducts: rings of complexity

Article Abstract:

Exocyclic DNA adducts are mutagenic lesions that can be formed by both exogenous and endogenous mutagens/carcinogens. It is also apparent that more information is needed for better understanding of the biological and structural implications of exocyclic adducts and their repair.

Cocarcinogens, Carcinogens

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The many colours of chromodomains

Article Abstract:

The information gained from the functional and structural studies of chromodomains with a bioinformatic classification of their structure is put forth. The results of the study show an unexpected diversity of interaction targets, including DNA, RNA and histones.

Histones, Chromatin, RNA, Computational biology, Structure

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