Prions in Saccharomyces and Podospora spp.: protein-based inheritance

Article Abstract:

P rotein-based inheritance and prions are discussed relative to Saccharomyces and Podospora spp. On the basis of genetic properties two non-Mendelian genetic elements of S. cerevisiae, called (URE3) and (PSI), are prposed to be prions, or infectious proteins of Ure2p and Sup35p, respectively. Topics include genetic criteria for a prion, a prion form of Ure2p affecting nitrogen catabolism, a prion form of Sup35p, a translation release factor, (Het-s)Hets prion control of vegetative incompatibility in Podospora, comparison of prion systems, and structure-based inheritance: cortical inheritance on Paramecium and other ciliates.

United States, Genetic aspects, Saccharomyces, Molecular microbiology, Scrapie

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Prions: proteins as genes and infectious entities

Article Abstract:

The term Prion means 'infectious protein' in any organism, irrespective of the mechanism and implies the absence of a nuclei acid necessary for the infectivity. Infectious proteins (Prion) include the transmissible spongiform encephalopathies (TSES) of mammals, the amyloidoses [URE3], [PSI] and [PIN] of Saccharomyces cerevisiac, [Het-s] of the filamentous fungus podospora anserina, and the self-activating in trans vocular protease B of yeast.

Science & research, Genetic research

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