Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis

Article Abstract:

Epoxide hydrolases plays an important role in the biodegradation of organic compounds and are potentially useful in enantioselective biocatalysis and analysis of various genomic databases reveals that about 20% of sequenced organisms contain one or more putative epoxide hydrolase genes. The results show that the expression of epoxide hydrolase genes that are detected by analyses of genomic databases is a useful strategy for obtaining new biocatalysts.

Bacterial genetics, Genetic research

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Trigonopsis variabilis D-amino acid oxidase: Control of protein quality and opportunities for biocatalysis through production in Escherichia coli

Article Abstract:

The flavoenzymes D-amino acid oxidases (DAOs) are used in the industrial conversion of cephalosporin C into glutaryl-7-aminocephalosporanic acid in the yeast Trigonopsis variabili. The recombinant TvDAO is analyzed for the catalycity in the Escherichia coli strains and show reduced toxicity in the microorganism.

Genetic aspects, Escherichia coli, Bacterial proteins

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Directed evolution of a thermostable phosphite dehydrogenase for NAD(P)H regeneration

Article Abstract:

An enzymatic system based on phosphite dehydrogenase from Pseudomonas stutzeri is developed to regenerate the reduced nicotinamide cofactors NADH and NADPH. Results would enable to reach the goal of developing a low-cost, highly efficient biocatalyst for NAD(P)H regeneration.

Physiological aspects, Pseudomonas, NAD (Coenzyme), Nicotinamide adenine dinucleotide

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