Domain structure and function within the QUTA proteins of Aspergillus nidulans: implications for the control of transcription

Article Abstract:

Previous research has shown that the expression of the eight genes of the quinic acid utilization (qut) gene cluster in Aspergillus nidulans is regulated by a positively acting regulatory protein named QUTA. To better understand the mechanism, the domain structure and function within the QUTA protein is analyzed. Northern blot experiments with messenger RNA support the view that the protein regulates the expression of the qut gene cluster. Western-blot and zinc-binding experiments show that zinc is binded in vitro by a putative zinc binuclear cluster motif within the N-terminus of the protein.

Proteins, Genetic regulation, Genetic transcription, Transcription (Genetics), Protein structure

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hymA (hypha-like metulae), a new developmental mutant of Aspergillus nidulans

Article Abstract:

Insertional mutation of the hymA (hypha-like metulae) gene of Aspergillus nodulans led to the development of aberrant hypha and conidiophore. Aspergillus nodulans hymA-mutants exhibited stunted hyphal growth. Abnormal hyphal development of the mutants were compared to wild-type Aspergillus nidulans which exhibited unicleated metulae compared to the multinucleated and elongated metulae of the mutants. Furthermore, mapping of the hymA gene indicated its role in the budding process and fungi cell differentiation.

Molds (Fungi), Mutagenesis

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The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds

Article Abstract:

Results indicate that Aspergillus nidulans mutants containing the ABC fungicide transporter AtrBp grow similar to the wild-type cells and exhibit increased sensitivity to agricultural fungicides and natural toxic compounds. Data also indicate that AtrBp overexpression prevents accumulation of the toxicants in the mutants.

Italy, Netherlands, Statistical Data Included, Drug resistance in microorganisms, Microbial drug resistance, Biological transport, Active, Active biological transport, Physiological regulation, Toxins, Fungicides

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