Dosage compensation in mammals: Fine-tuning the expression of the X chromosome

Article Abstract:

Mammals use a number of regulatory processes to ensure correct dosage of the X chromosome and this complexity of dosage compensation strategies is linked to the evolution of the sex chromosomes. New evidence showing that the X chromosome is globally up-regulated compared with autosomes is discussed.

Washington, Sexual behavior, Analysis, Comparative analysis, Marsupialia, Marsupials, X chromosome, Gene silencing, Eutherians

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Linking the hematopoietic microenvironment to imatinib-resistant P[h.sup.+] B-ALL

Article Abstract:

The article investigates the imatinib treatment of Philadelphia chromosome B-cell acute lymphocytic leukemia (B-ALL) with mutations in the BCR-ABL kinase domain and its response in the hematopoietaic microenvironment.

Gene expression, Lymphocytic leukemia, Philadelphia chromosome, Hematopoietic agents, Imatinib mesylate

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The secretory peptide gene EPF1 enforces the stomatal one-cell-spacing rule

Article Abstract:

The Epidermal Patterning Factor 1(EPF1) encodes a peptide in the stomatal cells that regulates the formation of guard cells surrounding the stomatal aperture.

Peptides, Stomata

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