Effect of salivary secretory IgA on the adhesion of Candida albicans to polystyrene

Article Abstract:

Saliva can inhibit the adhesion of Candida albicans to plastic when the fungus is in the germinating stage. The inhibition is mediated by saliva secretory IgA, which blocks adhesins on the cell wall surface of germ tubes. Adhesion of Candida to plastic dentures can cause denture stomatitis.

Physiological aspects, Saliva, Cell adhesion

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Variability in expression of antigens responsible for serotype specificity in Candida albicans

Article Abstract:

A study conducted on the expression of the antigens, serotype A and B, of Candida albicans shows that the serotype A is more reactive in acidic medium while serotype B is more reactive in alkaline medium. Indirect immunofluorescence shows that the monoclonal antibody B9E and the polyclonal monospecific antiserum against the antibody 6 in vitro react with the cell walls of the serotype A yeast cells but not with serotype B. However spectrofluorometry shows similar reactivity of both the serotypes.

Usage, Antibodies, Immunospecificity

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Effect of monoclonal antibodies directed against Candida albicans cell wall antigens on the adhesion of the fungus to polystyrene

Article Abstract:

The three monoclonal antibodies (mAbs) reactive with Candida albicans cell wall surface antigens on the adhesion of the fungus to polystyrene showed different effects on the germination and adhesion of C. albicans. No influence on germination or adhesion to polystyrene was observed in two C. albican strains for mAb 3D9. mAb B9E reduced both adhesion and filamentation, while mAb 21E6 decreased filamentation but increased adhesion. These varying effects by mAbs against C. albicans cell wall mannoproteins should be factored in formulating methods to block the adhesion of C. albicans to plastics with mAbs.

Analysis, Genetic aspects, Bacteria, Bacterial adhesion, Bacterial cell walls, Monoclonal antibodies

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