EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

Article Abstract:

Research has been conducted on the Eph receptors transducing repulsive short-range signals for axon guidance via actin dynamics modulation within growth cones. The cloning and characterization of the Eph receptor-interacting protein ephexin have been carried out and the results indicate the creation of the molecular link between Eph receptors and the actin cytoskeleton providing a localized regulation of the growth cone motility.

France, Cloning, Actin, Guanine, Nucleotides

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Multiple tumor suppressor pathways negatively regulate telomerase

Article Abstract:

Research has been conducted on telomerase regulation. The study of this genetic regulation has been carried out via the use of general genetic screen, and the results demonstrate that multiple tumor suppressor/oncogene pathways repress telomerase protein component expression, and that telomerase is reactivated via oncogenic mutations in human tumors.

Causes of, Gene mutations, Gene mutation, Gene expression, Tumors, Tumor suppressor genes, Telomerase, Tumours, Tumour suppressor genes

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An E3-like factor that promotes SUMO conjugation to the yeast septins

Article Abstract:

Research has been conducted on the ubiquitin-related protein SUMO. Results indicate that the covalent attachment of this protein to the other proteins participates in such processes as transcriptional regulation and growth control and that the Siz1 has been characterized as an E3-like factor in the SUMO pathway.

Genetic transcription, Transcription (Genetics), Metabolic regulation, Yeast, Yeast (Food product), Growth (Physiology)

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