Epigenetic spreading of the Drosophila dosage compensation complex from roX RNA genes into flanking chromatin

Article Abstract:

A model for X chromatin recognition by the dosage compensation complex in Drosophila is presented. Two genes, roX1 and roX2, are believed to be responsible for providing the entry sites for the MSL dosage compensation complex to recognize the male X chromosome. The roX1 gene, in particular, provides the nucleation site for the extensive spread of the MSL complex into flanking chromatin. The spreading can happen in cis or in trans between paired homologues despite being moved to an autosome.

Chromatin, Chromosomes, Cell physiology

---

Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila

Article Abstract:

Genetic analysis shows that dosage compensation in Drosophila is regulated primarily by the sex-lethal (Sxl) gene and hypertranscription depends on the autosomal male-specific lethal genes (msl) and maleless (mle). DNA binding experiments showed that Sxl prevents hypertranscription of the female X chromosomes by preventing mle from binding to the X chromosomes. In contrast, mle binding required the presence of the msl genes, leading to hypertranscription.

Dosage compensation (Genetics)

---

rox1 RNA paints the X chromosome of male Drosophila and is regulatd by the dosage compensation system

Article Abstract:

roX1 (RNA on the X), an X-linked gene from Drosophila, was cloned and characterized by reverse transcription-polymerase chain reaction and in situ hybridization. It produces RNAs that are male-specific, somatic and preferentially expressed in the central nervous system where it is regulated by a novel pathway. The subnuclear localization of roX1 RNA makes them candidates for an RNA component of the dosage compensation machinery.

Methods, Analysis, Usage, In situ hybridization, Polymerase chain reaction, Cloning, Molecular genetics

Similar abstracts:

• Abstracts: Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis
• Abstracts: Molecular genetics of the Drosophila melanogaster ovo locus, a gene required for sex determination of germline cells
• Abstracts: Differential amplification of rRNA genes by polymerase chain reaction. Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota
• Abstracts: The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
• Abstracts: Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.