Evidence for autosomal dominant inheritance of prostate cancer

Article Abstract:

A family-history cancer survey was sent to 5,486 men who underwent a radical prostatectomy for clinically localized prostate cancer, and 4,288 of them responded. No single-gene model of inheritance clearly accounted for familial aggregation of disease, but it could be partly explained by lack of Hardy-Weinberg equilibrium with an excess of homozygotes. It appears that the model that fits best is that for a rare autosomal dominant susceptibility gene, a model that fits best when probands are diagnosed before age 60. Genetic heterogeneity is likely.

Prostate cancer

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Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease

Article Abstract:

Planning for the use of sibs, parents, and unrelated controls for finding associations of disease with genetic markers is discussed with methods of computing sample size and power. Misleading associations can be avoided by using parents of disease cases as controls, but they may not be available unless the disease in an early-onset one, while sib controls may be easier to find.

Statistical Data Included, Planning, Usage, Diseases, Mathematical models, Human genetics, Parents, Genetic markers, Experimental design, Research design, Brothers and sisters, Medical statistics

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Transmission disequilibrium, family controls, and great expectations

Article Abstract:

Transmission/disequilibrium testing (TDT) is a useful method of genetic linkage analysis to determine genetic causes of complex diseases. TDT has been applied in the analysis of suspect gene regions, but it could be valuable in screening an entire genome. Applied to affected siblings within families, TDT can elucidate genetic and environmental interactions in disease.

Analysis, Statistics, Genetics

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