Formation of catechols via removal of acid side chains from ibuprofen and related aromatic acids

Article Abstract:

A yellow color, indicative of meta-cleavage accumulated transiently in the culture supernatant when Ibu-2 was grown on ibuprofen and when 3-flourocatechols was used to poison the meta-cleavage system, isobutylcatechols was identified in the culture supernatant through gas hromatography-mass spectroscopy analysis. In contrast to the widely distributed coenzyme A ligase, homogentistae or homoprotocatechuate pathway for metabolism of phenylacetic acid and similar compounds, Ibu-2 removes the acidic side chain of ibuprofen and related compounds prior to ring cleavage.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Ibuprofen Pain Relievers, Ibuprofen, Catechin

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Characteristics of Gloeophyllum trabeum alcohol oxidase, an extracellular source of [H.sub.2][O.sub.2] in brown rot decay of wood

Article Abstract:

The enzymes purified from the brown rot fungus having similar biochemical characteristics of alcohol oxidase (AOX) were analyzed. Results concluded that AOX play a crucial role in brown rot decay of wood.

Biodegradation, Oxidases, Wood, Structure, Chemical properties

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