From microbes to prions: The final proof of the prion hypothesis

Article Abstract:

A proof of prion hypothesis can be presented by engendering a prion into a natural host from an infectious prion produced in vitro. A study is conducted to produce a prion disease in a natural host from a prion, which is entirely generated in vitro using a PCR-like amplification system.

Host-bacteria relationships, Prion diseases

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Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of rabex-5

Article Abstract:

The catalytic core of the Rab GEF Rabex-5 is observed and is shown to have a tandem structure made up of Vps9 domain, stabilized by an essential helical bundle. Rab specificity, analyzed family-wise, demonstrates high selectivity for Rab5 subfamily GTPases.

All Other Miscellaneous Chemical Product and Preparation Manufacturing, Catalysts, Chemical preparations, not elsewhere classified, Analysis, Guanosine triphosphatase, GTPases

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Pursuing cardiac progenitors: Regeneration redux

Article Abstract:

The regenerative capacity of the heart following injury is debated. It is argued that the physiologic role and therapeutic potential of cardiac resident progenitor cells remain unclear.

Heart failure, Heart cells

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