Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia

Article Abstract:

A significant positive association is observed between the functional variants in the promoter region of the chitinase 3-like 1 (CHI3L1) gene and the genetic risk of schizophrenia in family-based and population-based investigations. The findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play a role in the predisposition to schizophrenia.

Hippocampus (Brain), Haplotypes, Report

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HLA-B maternal-fetal genotype matching increases risk of schizophrenia

Article Abstract:

A family-based candidate-gene study assesses maternal-fetal genotype matching at human leucocyte antigen-A (HLA-A), -B and -DRB1 as a risk factor of schizophrenia in offspring. The approach demonstrates the use of genetic markers to characterize the biology of prenatal risk factors of schizophrenia, and findings support the neurodevelopmental hypothesis of schizophrenia, and also suggest that the prenatal period is involved in the origin of this disease.

Usage, Risk factors, Genotype, Genotypes, Genetic markers

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Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene

Article Abstract:

A strong evidence for an association between schizophrenia and the gene of the key Glutathione (GSH)-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit is presented. It is observed that GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

Causes of, Glutamate, Genetic susceptibility

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