Trait components provide tools to dissect the genetic susceptibility of migraine

Article Abstract:

An alternative strategy is introduced using trait components, that is, individual clinical symptoms of migraine in order to determine affection status in genomewide linkage analyses of migraine-affected families. The findings suggest that the use of symptom components of migraine instead of the end diagnosis provides a useful tool in stratifying the sample for genetic studies.

Finland, Diagnosis, Migraine, Clinical report

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Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly

Article Abstract:

Methylation at the promoter region of the AXIN1 gene, which is implicated in caudal duplication anomalies, and in twin and age-matched singleton controls, is examined using bisulfite sequencing. Methylation of the promoter region in peripheral blood mononucleated cells is variable among the individuals, including monozygotic (MZ) pairs.

Netherlands, Medical examination, Methylation

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Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

Article Abstract:

Several genome-wide analyses are conducted to study the DNA copy-number variations (CNVs) in the phenotypically concordant or discordant monozygotic twins. The twins are found to exhibit different CNV profiles, hence giving a better insight into their disease-predisposition loci.

Chromosome replication, Somatic cells, Single nucleotide polymorphisms

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