The right place at the right time: Regulation of daily timing by phosphorylation

Article Abstract:

A new approach is used to understand phosphorylation of the mouse PERIOD2 (PER2) (mPER2) protein, leading to novel experiments showing how alternation of phosphorylation state leads to either a clock that is slow and late or fast and early. An extended 'kinase-substrate pair feed-back loop II module' is found to be a part of the core clock mechanism generating the 24-hour oscillation at the molecular level.

Germany, Analysis, Genetic aspects, Human genetics, Phosphorylation

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Circadian transcription: Passing the HAT to CLOCK

Article Abstract:

Circadian clocks control physiological, metabolic, and behavioral rhythms in organisms ranging from cyanobacteria to humans. The rhythms in histone acetylation are necessary for rhythmic transcription and CLOCK, a key transcription factor essential for circadian oscillator function, is the histone acetyl transferace which is responsible for the rhythm.

Histones, Genetic research

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