Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants

Article Abstract:

A genome-wide RNA interference (RNAi) screening is conducted to identify genes necessary for the extended life span of daf-2 mutants and gene inactivations that shorten daf-2 life span. The gene inactivations have disrupted the increased expression of the DAF-16 downstream gene superoxide dismutase sod-3 in a daf-2 mutant, suggesting trafficking between the insulin-like receptor and DAF-16.

Gene expression, Genetic transcription, Transcription (Genetics), Mutation (Biology), Mutation, RNA interference

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Conservation of the global sex determination gene tra-1 in distantly related nematodes

Article Abstract:

The functional conservation of the tra-1 gene in sex determination of Pristionchus pacificus and Caenorhabditis elegans is studied. The study is said to provide the first example of the functional conservation of a global sex determination regulator in two distantly related species of the same phylum.

Genetic research

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