Genome-wide identification of replication origins in yeast by comparative genomics

Article Abstract:

Study is conducted to determine genome-wide location of replication origins at a resolution sufficient to identify the sequence elements bound by replication proteins and to demonstrate that most replication origin sequences are phylogenetically conserved among closely related Saccharomyces species. The results show that phylogenetic conservation can be used to identify the origin sequences responsible for replicating enkaryotic genome.

Scotland, Analysis, Eukaryotes, Phylogeny, Chromosome replication, Yeast fungi, Yeasts (Fungi)

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Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically mutant

Article Abstract:

Isw2 ATP-dependent chromatin-remodeling activity is targeted to early meiotic and MATa-specific gene promoters in Saccharomyces cerevisiae. However, no evidence was found for Isw2 function at sites preferentially enriched by wild-type Isw2p, leading to the proposal that wild type Isw2p cross-linking revealed a scanning mode of the complex as it surveyed the genome for its targets.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Chromatin, Adenosine triphosphatase, Brewer's yeast, Saccharomyces cerevisiae, ATPases, Retrotransposons

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