Hematopoietic reconstitution with androgenetic and gynogenetic stem cells

Article Abstract:

Uniparental fetal liver cells were transplanted into lethally irradiated adult mice to test their capacity to replace adult hematopoietic tissue. The evidence suggests that transplanted uniparental cells could proliferate in and even replace an adult organ substantiating the concept of using derivatives of uniparental embryonic stem cells for transplantation.

Health Care and Social Assistance, HEALTH SERVICES, Surgical Transplants, Transplantation of organs, tissues, etc., Transplantation, Parthenogenesis, Stem cell research

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Overreplication of short DNA regions during S phase in human cells

Article Abstract:

High-resolution polymerase chain reaction (PCR) strategy is developed to localize DNA replication origins (ORIs) directly on a total unfractionated human DNA. A short region of ~200-base-pair overlapping well-characterized replication origins undergo many rounds of replication, coinciding with their specific time of activation during S phase.

Research and Development in the Physical, Engineering, and Life Sciences, Genetic Engineering, Polymerase chain reaction, DNA replication

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Multipotential differentiation ability of GATA-1-null erythroid-committed cells

Article Abstract:

Myeloid and mast cells are induced from the GATA-1-null proerythrophase by the simulation granulocyte-macrophase colony-stimulating factor and interleukin-3erythroid-committed cells, respectively. Data suggests that GATA-1 is a critical transcription factor to fix erythroid progenitors to the erythroid lineage.

Mast cells, Granulocyte-macrophage colony stimulating factor

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