Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

Article Abstract:

Mad1 forms a complex with mSin3A and HDAC as evidenced by immunoprecipation by using [S]methionine-labeled 293epithelial cells. HDAC and Mad bind to separate regions of mSin3 as proved by using immunoprecipitation and transfection of 293 with plasmids expressing Mad1, HA-tagged Mad1, and HA-tagged Mad3. Mad1 repression requires histone deacetylase activity through formation of a ternary comlex with mSin3A and HDAC1/2 as proved by the effect of a specific histone deacetylase inhibitor on Mad1 transcriptional activity.

Cytology, Animal genetics

---

Linker histone H1 regulates specific gene expression but not global transcription in vivo

Article Abstract:

Previous research have failed to fully explain the role of linker histone in transcription in vivo. One way to remedy this problem is to look at Tetrahymena thermophila, a model system which provides a unique opportunity for elucidating on the linker histone function. Experiments show that the linker histone H1 knockout strain of Tetrahymena thermophila has no major effect on global transcription, although it acts as either a positive or negative gene-specific regulator of transcription in vivo.

---

A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense

Article Abstract:

A study was performed to demonstrate that the serum-resistance-associated (SRA) gene is an expression site-associated gene of the Edinburgh trypanozoon antigen type 1.10 (ETat 1.10) expression site. The SRA gene was encoded a variant surface glycoprotein-like protein and was only present in the R clones of the ETat strain of the Trypanosoma brucei rhodesiense resistant to normal human serum. Results revealed that SRA resulted to the resistance of the organism against normal human serum.

Drug resistance in microorganisms, Microbial drug resistance, Serum, Blood serum, Trypanosoma brucei

Similar abstracts:

• Abstracts: Global analysis of siRNA-mediated transcriptional gene silencing. To SIR with Polycomb: Linking silencing mechanisms
• Abstracts: Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV type 1 transmission and AIDS disease progression
• Abstracts: Detection and identification of fungi intimately associated with the brown seaweed Fucus serratus. Diversity of sulfur isotope fractionations by sulfate-reducing prokaryotes
• Abstracts: An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3
• Abstracts: Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.