Global analysis of siRNA-mediated transcriptional gene silencing

Article Abstract:

The global patterns of gene expression and chromatin modifications produced by RNAi machinery in fission yeast are determined with the help of two papers by Hansen and all and Cam and all. The studies showed that transposable elements in general are seldom targets of siRNA-mediated silencing, but the data from Arabidopsis profiling and Drosophila siRNA libraries, among other data, indicate that transposable elements are routinely targeted for silencing through histone modification.

Arabidopsis

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Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history

Article Abstract:

The manifold effects of juvenile hormone (JH), the most versatile animal hormone, with an emphasis on the fruit fly Drosophila melanogaster, an organism amenable to both genetics and endocrinology is reviewed. Although the effects of JH signaling can vary greatly among species JH typically has negative effects on stress resistance, immune function and lifespan, yet exerts positive effects on reproduction.

Genetic research, Endocrinology, Pleiotropy

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To SIR with Polycomb: Linking silencing mechanisms

Article Abstract:

Yeast SIR2, the most evolutionarily conserved deacetylase, plays an essential role in epigenetic silencing at the silent mating type loci and telomeres. The discovery that Drosophila SIR2 is also involved in epigenetic silencing mediated by the Polycomb group proteins and is physically associated with a complex containing the E(Z) histone methyltransferase has wide implications is discussed.

Methyltransferases

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