Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription

Article Abstract:

The stability of a locus' tissue-specific open chromatin structure is initiated and maintained through locus control regions (LCRs), which, in transgenic mice, confer high level expression on linked genes regardless of the genes' position in the mouse genome. However, LCRs lose this capability when they are integrated into heterochromatic regions because of the presence of two disruption mechanisms. In this case, heterochromatic silencing can be overcome with a complete LCR, which also controls for the level of transcription by ensuring activity in cells at all times.

Genetic transcription, Transcription (Genetics)

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Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

Article Abstract:

The first functional evidence of the role of the most active sites of the locus control region (LCR) and the promoter of the beta-globin gene in the maintenance of the active chromatin hub (ACH) is provided. It is concluded that multiple interactions between the LCR and the beta-globin gene are required to maintain the appropriate spatial configuration in vivo.

Genetic regulation

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Regulation of neuron survival and death by p130 and associated chromatin modifiers

Article Abstract:

The molecular mechanism by which cell cycle molecules regulate neuron survival and death are addressed. The study reveals that p130 with E2F4 and chromatin modifiers including histone deactylases (HDAC) and Suv39H1 play an essential role in maintaining neuron survival and do so by repressing pro-apoptotic genes such as B-myb.

United States, Histones, Apoptosis

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