Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

Article Abstract:

Researchers have investigated the mechanism by which an elongated polyglutamine sequence leads to neurodegeneration in Huntington's disease (HD). This work involved using exon 1 of the HD gene with expanded CAG repeats for the production of glutamthione S-transferase (GST)-HD fusion proteins in E. coli. The findings raise the possibility that HD, DRPLA, SBMA, SCA1, SCA2 and SCA3 are the result of a toxic amyloid fibrillogensis. The presence of amyloid-like fibrils has not previously been seen in these inherited diseases.

Causes of, Amyloidosis, Huntington's chorea, Huntington's disease, Degeneration (Pathology)

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Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

Article Abstract:

The beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription is demonstrated. Vertebrate BCL9-2 proteins show an overall amino acid sequence identity of 60% and 35% identity to the human proto-oncogene product BCL9.

Analysis, Genetic transcription, Transcription (Genetics), Proto-oncogenes, Binding proteins

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A human protein-protein interaction network: A resource for annotating the proteome

Article Abstract:

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. Systematic human protein interaction screens can lead to a more comprehensive understanding of protein function and cellular processes.

Protein research, Proteomics

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