IKKbeta links inflammation and tunorigenesis in a mouse model of colitis-associated cancer

Article Abstract:

A study is conducted to show that although deletion of IKKBeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size. A key player in inflammation is transcription factor NF-kB whose activity is triggered in response to infectious agents and proinflammatory cytokines via the IkB kinase (IKK) complex.

Analysis, Protein kinases, Cytokines, Tumor proteins, Tumour proteins

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

Article Abstract:

It is investigated whether I (sub k) B kinase beta (IKKbeta) is involved in chemically induced liver cancer, which is a model not involving overt inflammation. IKKbeta orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis.

Liver cells, Hepatocytes, Carcinogenesis, Liver cancer, Genetic research

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The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP turnover

Article Abstract:

The turnover of the NF-KB-induced antiapoptotic protein C-FLIP is accelerated by tumor necrosis factor (TNF) alpha-mediated Jun kinase (JNK) activation. JNK promotes the proteasomal elimination of c-FLIP and thus antagonizes NF-KB during TNF alpha signaling.

California, Physiological aspects, Cell death, Tumor necrosis factor, Rats, Ubiquitin, Properties, Rattus, Tumour necrosis factor

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