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The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

Article Abstract:

Kaiso, a p120 catenin partner, has been found to be a DNA methylation-dependent transcriptional repressor. A novel mammalian DNA binding activity that must have at least two symmetrically methylate CpG dinucleotides in its recognition sequence, preferably in the sequence 5'CGCG is described. Zinc-finger motifs appear to be responsible for DNA binding.

Author: Wilm, Matthias, Bird, Adrian, Hendrich, Brian, Prokhortchouk, Anna, Jorgensen, Helle, Ruzov, Alexei, Georgiev, Georgii, Prokhortchouk, Egor
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
United States, Germany, Scotland, Russia, Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Mammals, DNA binding proteins, Methylation

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Identification and purification of two distinct complexes containing the five RAD51 paralogs

Article Abstract:

Identification and purification has been carried out for two distinct complexes containing the five RAD51 paralogs. The extreme sensitivity of paralog-defective cell lines to cross-linking agents has been found to be traceable to defects in the processing of incised cross links and to resulting failure to start recombinational repair at certain sites.

Author: Masson, Jean-Yves, Tarsounas, Madalena C., Stasiak. Andrzej, Stasiak, Alicia Z., Shah, Raivee, Mellwraith, Michael J., Benson, Fikona E., West, Stephen C..
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
Statistical Data Included, DNA repair, Genomes, Genetic recombination

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Subjects list: United Kingdom, Research, Physiological aspects, Cytochemistry
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