Implication of membrane localization of target mRNA in the action of a small RNA: Mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli

Article Abstract:

The implication of membrane localization of target mRNA in the action of a small RNA is studied in the context of the mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli. It can be concluded that the mRNA localization to the inner membrane coupled with the membrane insertion of nascent peptide is responsible for mediating the Hfq/ small antisense RNA- (SgrS) dependent ptsG mRNA destabilization and reducing second rounds of translation.

Membrane proteins, Messenger RNA

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Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast

Article Abstract:

A study to show that the level of protein product of nonstop mRNA containing a poly(A) tail was reduced 100-fold due to rapid mRNA degradation, translation repression, and protein destabilization partially by the proteasome was conducted. Results suggest that translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization.

Yeast fungi, Yeasts (Fungi), Genetic translation, Translation (Genetics), Ubiquitin-proteasome system

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RNase E-based ribonucleoprotein complexes: Mechanical basis of mRNA destabilization mediated by bacterial noncoding RNAs

Article Abstract:

The question of how Hfq-binding antisense small RNAs of Escherichia coli, SgrS and RyhB, cooperate with RNase E to destabilize the target mRNAs is addressed. RNase E forms variable ribonucleoprotein complexes with Hfq/small RNAs through its C-terminal scaffold region.

Antisense DNA, Ribonucleoproteins

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