In vitro guidance of retinal ganglion cell axons by RAGs, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

Article Abstract:

Purification and cloning of a glycosylphosphatidylinositol (GPI)-anchored, 25 kDa glycoprotein named as RAGS shows that the recombinant protein induces growth cone collapse and repulsion of retinal ganglion cell axons. These phenomena are observed in temporal as well as nasal axons showing that additional activity is necessary to confer the nasotemporal specificity. The sequence of repulsive axon guidance signal (RAGs) shows significant homology to the receptor tyrosine kinase ligands.

Research, Glycoproteins, Ganglia

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Ptdlns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

Article Abstract:

Immunoreceptor signaling analyses have confirmed the possibility of controlling phospholipase Cgamma (PLCgamma)-dependent IP3 production and sustained calcium influx via the blockage of phosphatidylinositol-3,4,5-triphosphate accumulation. This can be observed from a model of receptor-mediated regulation of PLCgamma function that includes Ptdlns-3,4,5-P3. Ptdlns-3,4,5-P3 plays a role in the signaling pathway used by tyrosine kinases for producing IP3.

Phospholipases

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Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3

Article Abstract:

Bovine protein S (PS) is identified as a ligand for human Rse/Tyro 3 and found that human PS (hPS) acts as a potent ligand for murine Rse/Tyro 3 but human Gas6 acts as a ligand for hRse/Tyro 3. hPS induces Rse/Tyro 3-mediated responses in NIH 3T3 cells. Human Rse/Tyro 3 prefers human Gas 6 over hPS while mRse/Tyro 3 prefers hPS over hGas 6.

Ligands (Biochemistry), Protein S

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