Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction

Article Abstract:

The precise sensing of morphogen concentrates by cells is crucial for correct cell fate patterning in embryonic development. The experiments conclude that basis for memory is the long-lasting residence of a signaling complex in the endo-lysosomal pathway and the regulated duration of this step helps to determine the choice of gene expression resulting from gradient interpretation.

Tumors, Embryonal, Embryonal tumors, Embryonal tumours

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Gas1 extends the range of Hedgehog action by facilitating its signaling

Article Abstract:

The signaling of morphogen- Hedgehog is essential for the process of development in mammals. The Growth Arrest-specific Gene 1(GAS1) facilitates the binding of Hedgehog with Patched 1 and increases the signaling activity.

Genetic research, Hedgehogs

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Autophagy: process and function

Article Abstract:

Autophagy is an intracellular degradation system of the lysosome and also plays a variety of physiological and pathophysiological roles. The process and role of autophagy is discussed in a process-based manner.

Analysis, Phagocytosis, Krebs cycle

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