Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice
Article Abstract:
Research demonstrates that neutrophil elastase mediates the fusion protein PML-RARalpha initiation of acute promyelocytic leukemia. Results show that the neutrophil elastase is produced in promyelocytes. Data indicate that hematopoietic proteases may have a role in leukemia development.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Analysis, Causes of, Physiological aspects, Leukemia, Neutrophils, Scission (Chemistry), Elastases
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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RNAi: RISC gets loaded
Article Abstract:
Simplified views of siRNA-programmed RISC activation are explored. A heterotrimeric complex from humans is defined that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Science & research, Research, Messenger RNA, RNA interference
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Subjects list: United States
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