Abstracts - faqs.org

Abstracts

Biological sciences

Search abstracts:
Abstracts » Biological sciences

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

Article Abstract:

New research has shown that Rel-NF-kappaB physiologically regulates expression of a Bcl-2-like protein that is critical for the control of cell survival during lymphocyte activation. In normal B and T cells, it was found that expression of the Bcl-2 prosurvival homolog, A1 is quickly induced in a Rel-dependent way by mitogens. In B-cell lines from c-rel-/- mice, which are subject to apoptosis as a result of antigen receptor ligation, constitutive expression of an A1 transgene takes away that pathway to cell death.

Author: Gerondakis, Steve, Grumont, Raelene, Rourke, Ian J.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
Australia, Causes of, Observations, Cell death, Antigen receptors, T cell, T cell antigen receptors, Genetic transcription, Transcription (Genetics), B cells, Cell differentiation, Mitogens, Lymphocytes

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation

Article Abstract:

A study reveals that 46 unique residues within an 86-residue segment of the Rel homology region of c-Rel are responsible for the c-Rel requirement for Il12b gene induction by lipopolysaccharide in bone marrow-derived macrophages. The unique functions of closely related transcription factor family members can be dictated by difference in the range of DNA sequences recognized at high affinity, despite having similar binding site consensus sequences and DNA contact residues.

Author: Natoli, Gioacchino, Smale, Stephen T., Williams, Kevin J., Hoffmann, Alexander, Sanjabi, Shomyseh, Saccani, Simona, Liang Zhou, Ghosh, Gourisankar, Gerondakis, Steve
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
Genetic aspects, Macrophages, Bone marrow

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response

Article Abstract:

The functional roles of SWI/SNF and Mi-2beta complexes during gene activation in macrophages in response to lipopolysaccharide (LPS) stimulation were studied using retroviral RNAi strategy. The results suggested that the ATP-dependent nucleosome remodeling complexes might be attractive targets for modulating the strength of an inflammatory response or other inducible responses.

Author: Smale, Stephen T., Imbalzano, Anthony N., Ramirez-Carrozzi, Vladimir R., Nazarian, Aaron A., Caiyi, Li C., Gore, Sarah L., Sridharan, Rupa
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
Chromatin, Cytokines, Chemical properties

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Polysaccharides
Similar abstracts:
  • Abstracts: Synapse-specific and neuregulin-induced transcription require an Ets site that binds GABP alpha/GABP beta. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
  • Abstracts: The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages
  • Abstracts: Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria. Microbial dextran-hydrolyzing enzymes: Fundamentals and applications
  • Abstracts: Reduction of nitroaromatic compounds mediated by Streptomyces sp. exudates. Activity and diversity of methanogens in a petroleum hydrocarbon-contaminated aquifer
  • Abstracts: Methylmercury oxidative degradation potentials in contaminated and pristine sediments of the Carson River, Nevada
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.