Inferring selective history from multilocus frequency data: Wright meets the Hamiltonian

Article Abstract:

The features of the changing patterns of a two-locus, two-allele population genetic model have been studied without specifying in advance the form of selection. A continuous time genetic model was used to ascertain the minimum time required to go from the initial to the final condition after initial and final genotypic frequencies had been specified. The study shows that in a few hundred generations, significant linkage disequilibrium can be produced from initial linkage equilibrium, provided recombination is not significantly larger than selection.

Linkage (Genetics)

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Estimating polygenic models for multivariate data on large pedigrees

Article Abstract:

Expectation L-maximization algorithm was developed to approximate the quantitative traits in extensive lineages using additive genetic models. The application of the technique in the analysis of multivariate data is discussed. Analyses of bivariate data from a snail, Lymnaea elodes, population consisting of 949 individuals in four generations and that for a 400-member population of the guppy, Poecilia reticulata, in three generations were given as examples.

Methods, Multivariate analysis

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Fixation probabilities under partial selfing when heterozygotes are intermediate in viability

Article Abstract:

Two mistakes made in an earlier method for the approximation of the survival probability of a mutant is presented. An estimation formula approximating the probability of an allele A fixed in a selfing population of size N with a frequency of p. Assumptions in the model include a weak selection and an intermediate characteristic of heterozygotes relative to dominant and recessive homozygotes.

Heterozygosis, Heterozygote, Inbreeding

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