Persistence of repeated sequences that evolve by replication slippage

Article Abstract:

Replication slippage is a mechanism which increases or reduces the number of short, tandemly repeated sequences during DNA replication The evolution of short repeat sequences by replication slippage was modelled using a linear birth and death process. The analyses showed that the distributions of life expectancy and age have long tails. A large coefficient of variation was found for the estimate for conditional variance. These resultswere used to test the model using the persistent repeat sequences in the flanking region of the primate beta-globin genes and in the chloroplast DNA of Oenothera. One sequence in Oenothera did not conform to the neutral model.

Models, DNA, Chloroplasts, Evolution (Biology), Evolution, Chemical evolution, Molecular evolution, Plant chromosomes

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The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae

Article Abstract:

The phenotypes associated with mutations influencing the large subunit of replication factor C in sacchromyces cerevisiae were characterized using genetic and biochemical techniques. It was revealed that Cdc44p played an essential role in DNA replication and DNA repair in vivo. Moreover, it was discovered that Cdc44p mutants experienced a delay in traversing S phase at certain restrictive temperatures. In addition, the mutants developed higher levels of single-strand DNA breaks than wild-type cells after being subjected to ultraviolet radiation. The results suggest that Cdc44p plays an active role in the reconstruction of DNA gaps.

Genetic aspects, DNA damage, Saccharomyces

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Polymorphism with regard to the presence or absence of an element

Article Abstract:

A population genetic model of insertion of short interspersed repetitive DNA elements (SINEs) into a specific genome location was designed. The evolution model was constructed assuming parameters such as the rare deletion of SINES which result in the confinement of multiplication to a specific period, the ability of only a few mastercopies to expand the multiplication and the existence of non-equilibrium state. The model was used to calculate the multiplication period and derive relationships among populations.

Genetic polymorphisms

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