Information-theoretic metrics for visualizing gene-environment interactions

Article Abstract:

The dependence of candidate visualization metrics on biological and study-design factors were assessed by developing heuristics for visualizing and interpreting gene-environment interactions (GEIs). The k-way and interaction information (KWII) and total correlation information (TCI) were found to be promising metrics for visualizing GEIs.

United States, Evaluation, Cancer, Experimental design, Research design, Report

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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

Article Abstract:

The article discusses the identification of a component, TINF2, of the shelterin telomere protection complex in patients suffering from dyskeratosis congenita (DC). The analysis proves that TINF2 is easily mutated in DC and in Revesz syndrome.

Physiological aspects, Telomeres, Epithelial cells, Dyskeratosis congenita

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