Segment-polarity mutations cause stripes of defects along a leg segment in Drosophila

Article Abstract:

A study was conducted on the effects of mutations in 6 segment-polarity (SP) genes and their 15 pairwise compounds on bristle patterns in the second-leg barsitarsi of Drosophila. Results revealed that abnormal patterning within defined areas of the imaginal discs were produced by SP mutations. In particular, specific rows, or portions of them, have been deleted and bristle number increased within or between specific rows. These abnormalities were linked to width changes in different parts of the circumference and suggested that altered bristle patterns might have been mediated by regional growth perturbations.

Abnormalities, Leg, Insects, Mutation (Biology), Mutation, Animal morphology

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A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb

Article Abstract:

Researchers discovered a homeobox-containing gene, Prx-1, isolated from the chick limb bud cDNA library. The homeodomain sequence is associated with Drosophila paired and gooseberry and mouse Pax-3, Pax-6 and Pax-7. The Prx-1 homeodomain protein is related to the differentiation of bone, muscle and other tissues of mesodermal origin during limb growth.

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