Inheritance of astigmatism: evidence for a major autosomal dominant locus

Article Abstract:

Evidence supports a single-major-locus model for inheritance of corneal astigmatism, suggesting that genetic linkage studies could be conducted with multiplex families of severely affected individuals. The POINTER and COMDS programs were used to perform complex segregation analysis on data from 125 nuclear families of people with astigmatism. Alternative genetic models could not be eliminated by POINTER, but COMDS supported single-major-locus inheritance after the severity parameter was included.

Research, Linkage (Genetics), Astigmatism

---

A susceptibility locus for bipolar affective disorder on chromosome 4q35

Article Abstract:

A susceptibility locus for bipolar affective disorder (BAD) has been identified on chromosome 4q35. Significant LOD scores were obtained for four microsatellite markers: D4S1652, D4S408, D4S2924 and D4S171. A genome screen was conducted for 214 microsatelite markers in a large Australian pedigree, and genotypes for an additional 10 pedigrees were examined for the four microsatellite markers.

Bipolar disorder

---

Similar abstracts:

• Abstracts: Genetic identification of chemotactic transducers for amino acids in Pseudomonas aeruginosa
• Abstracts: Production of putative virulence factors by Renibacterium salmoninarum grown in cell culture. Physical map of the chromosome of Aeromonas salmonicida and genomic comparisons between Aeromonas strains
• Abstracts: The complexity of p53 modulation: emerging patterns from divergent signals. CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
• Abstracts: Rapid clearance of fetal DNA from maternal plasma. Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis
• Abstracts: Inactivation of two haemolytic toxin genes in Aeromonas hydrophila attenuates virulence in a suckling mouse model

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.