Rapid clearance of fetal DNA from maternal plasma
Article Abstract:
Clearance of circulating fetal DNA in maternal plasma after delivery has been studied using quantitative PCR analysis of the sex-determining region Y gene as a marker for male fetuses. Plasma samples from 12 women were analyzed 1-42 days after males were born. The mean half-life for circulating fetal DNA was 16.3 min, the range being 4-30 min. Plasma DNA analysis may be less susceptible to false-positive results due to carryover from other pregnancies than detection of fetal cells in maternal blood. The quick clearance may be useful for monitoring feto-maternal events that occur rapidly.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis
Article Abstract:
Correlation between genotype and phenotype has been examined in 14 families with autosomal recessive lamellar ichthyosis. The results show no consistent correlation between genetic and clinical classifications, suggesting that existing clinical criteria do not discriminate between the different molecular forms of the disease. Three loci have been associated with lamellar ichthyosis. In families with mutations on the TGM1 gene, seven different missense mutations and one splice mutation have been found.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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