Structure, function, and biology of SHIP proteins

Article Abstract:

Sequential details on the structure and biological function of SH2-containing inositol 5'-phosphatase (SHIP) are presented in this review article with critical analysis of the role overall of SHIP in cellular regulation. SHIP has been identified as a signaling protein component of many growth factor receptor signaling pathways.

Structure-activity relationships (Biochemistry), Hematopoiesis

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Intercellular signals regulating pancreas development and function

Article Abstract:

Intercellular signals that regulate pancreas function and development are discussed in this review article with the focus on findings that may shed light on mechanisms behind human pancreatic exocrine and endocrine diseases. Relationships and likely relationships between pancreatic signaling that is cell-extrinsic and transcriptional regulators of pancreatic gene expression transcriptional regulators are covered.

Diabetes, Diabetes mellitus, Hormones, Genetic regulation, Cell interaction, Pancreas, Exocrine glands

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Cellular survival: a play in three Akts

Article Abstract:

Cell survival is discussed in this review article. The ability of trophic factors to promote survival have been attributed, partly at least, to the phosphatidylinositide 3'-OH kinase (PI3K)/c-Akt kinase cascade. Various targets of the PIcK/c-Akt signaling pathway have been identified recently and they may underline ability of the regulatory cascade to contribute to survival.

Statistical Data Included, Cell death, Neurons

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