Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 2OP3

Article Abstract:

A bacteriocin-like inhibitory substance was purified from freeze-thaw extracts of Streptococcus salivarius 2OP3. Amino acid composition and preliminary sequence determination showed that the substance, designated salivarcin A, is a lantibiotic. The N terminal sequence was used as a probe to identify the structural gene, salA. Gene sequence analysis showed that the secondary structure of salivaricin A is also similar to type A lantibiotics.

Antibiotics, Identification and classification

---

Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva

Article Abstract:

A highly specific Salivaricin A (SalA) induction system is used to directly detect the presence of SalA in the saliva of humans who either harbor populations of SalA-producing Streptococcus Salivarius or who have been colonized with the SalA2-producing probiotic S. Salivarius K12. Four additional variants SalA2 to Sal A5 are identified.

---

Safety assessment of the oral cavity probiotic Streptococcus salivarius K12

Article Abstract:

Safety data relating to Streptococcus salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants are reported. The microbial composition of saliva following the dosing of subject with K12 is examined.

Similar abstracts:

• Abstracts: Purification and characterization of a keratinolytic serine proteinase from Streptomyces albidoflavus. Biochemical and genetic characterization of coagulin, a new antilisterial bacteriocin in the pediocin family of bacteriocins, produced by Bacillus coagulans I(sub 4)
• Abstracts: Isolation and partial characterization of an 87-kilodalton beta-1,3- glucanase from Bacillus circulans IAM1165
• Abstracts: Isolation and characterization of an acidophilic, heterotrophic bacterium capable of oxidizing ferrous iron. Enumeration and characterization of acidophilic microorganisms isolated from a pilot plant stirred-tank bioleaching operation
• Abstracts: Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain streptococcus salivarius K12
• Abstracts: Investigation of the effect of combined variations in temperature, pH, and NaCl concentration on nisin inhibition of Listeria monocytogenes and Staphylococcus aureus

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.