Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain streptococcus salivarius K12

Article Abstract:

The characterization of commercial probiotic Streptococcus salivarius strain K12 which is the prototype of those Streptococcus salivarius strains that are the most strongly inhibitory in a standardized test of streptococcal bacteriocin production was reported. The genetic loci encoding 2,368-Da salivaricin (SalA2) and 2,740-Da salivaricin B (SboB) in strain K12, which was fully characterized, was found to be localized nearly adjacent sites on pSsal-K12, a 190-kb megaplasmid.

Analysis, Streptococcus, Bacteriocins, Nucleotide sequencing

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Cloning of the gene encoding streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence

Article Abstract:

The cloning and sequencing of the SA-FF22 structural gene (scnA) is described and its relationship to lantibiotics is discussed. Streptococcus pyogenes FF22 produces streptococcin A-FF22 (SA-FF220), a lantibiotic. 51-amino acid prepeptide is encoded by the nucleotide sequence of the SA-FF22 structural gene (scnA).

Nucleotide sequence, Base sequence, Cloning

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Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes

Article Abstract:

Research has been conducted on Streptococcus pyogenes strains inhibiting the growth of all indicators in a streptococcal bacteriocin typing scheme. Results demonstrate that this inhibitory profile is caused by type A1 lantibiotic streptin.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, New Zealand, Bacteriostats, Antibiotics, Environmental aspects, Antibacterial agents, Growth, Microbiology, Streptococcus pyogenes, Company growth, Microbial ecology

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