JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye

Article Abstract:

The interaction of JUN and Pointed (PNT) protein induces the formation of R7 photoreceptor neurons in the Drosophila eye. The activity of JUN and PNT on the phyllopod (phyl) gene, a transcriptional target of the RAS pathway during R7 differentiation, induces the differentiation. Targeting the proteins to one promoter results in cooperative binding of JUN to the ETS domain of PNT. The binding is inhibited by YAN, which suppresses R7 differentiation, and phyl.

Observations, Proteins, Drosophila, Photoreceptors

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

Article Abstract:

A demonstration is presented that the protein kinase mammalian Ste20-like kinases (MST1) mediates oxidative stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. The MST-FOX signaling link is extended to nematodes.

Science & research, Genetic aspects, Cell death, Mammals, Genetic research, Oxidative stress

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