Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker

Article Abstract:

A study was conducted on Dpp, a TGFbeta which organizes pattern in the Drosophila wing by assuming the function of a graded morphogen, activating various targets above distinct threshold concentrations. It was observed that Dpp can regulate gene expression indirectly by downregulating the expression of the brinker gene, which encodes a putative transcription factor that acts to repress Dpp targets. The medial-to-lateral Dpp gradient along the anterior-posterior axis is complemented by a lateral-to-medial gradient of Brinker.

Gene expression, Polypeptides

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Trimeric G protein-dependent frizzled signaling in Drosophila

Article Abstract:

The roles for the G alpha o subunit (Go) in mediating the two distinct pathways transduced by frizzled (Fz) receptors in Drosophila, the Wnt and planar polarity pathways are presented. The results reveal that Go is likely part of a trimec G protein complex that directly transduces Fz signals from the membrane to down-stream components.

G proteins, Genetic research

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Translational repression by Biocoid: Competition for the cap

Article Abstract:

The action of the Drosophila Biocoid morphogen in formation of the caudal protein gradient is discussed and in doing so a new mechanism of translational repression is described. The 4EHP recruited to caudal mRNA by Biocoid binds the 5' cap, excludes eIF4E, and thus prevents eIF4E-dependent initiation of translation.

Embryology, Experimental, Embryological research, Genetic translation, Translation (Genetics)

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