Linking colorectal cancer to Wnt signaling

Article Abstract:

The review examines the etiology of human colorectal cancer from the point of independent genetic deviations such as beta-catenin deregulation leading to malignancy in the gut epithelium, Adenomatous polyposis coli influencing tumor progression, and finally the central role of the Wnt siganaling pathway.

United Kingdom, Netherlands, Colorectal cancer, Genetic aspects, Carcinogenesis, Canonical correlation (Statistics)

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Wnt/[beta]-catenin signaling in development and disease

Article Abstract:

The roles of the canonical Wnt signaling pathway, which are activated by Wnt proteins, in development, tissue self-renewal and cancer are examined. Wnt signaling is involved in every aspect of embryonic development, where it controls homeostatic self-renewal in many adult tissues and somatic mutations are associated with cancer of the intestine and many other tissues.

Science & research, Genetic disorders, Neurotrophic functions, Neurotrophins, Report

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LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic

Article Abstract:

The role of the lymphocyte enhancer binding factor 1 (LEF-1) in the regulatory feedback loop between Ultrabithorax (Ubx) and wingless (wg) in the wingless signaling pathway was investigated. The results confirmed the presence of a wg response sequence (WRS) in the visceral mesoderm enhancer from Ubx which was identified to be a binding site for mammalian LEF-1. It was also shown that LEF-1 can form a stable complex with arm protein on the Ubx WRS and that its function of enhancing transcription requires dpp signaling. Such findings indicate that LEF-1 coordinates and regulates the assembly of multiprotein enhancer complexes.

Electrophoresis, Embryology, Animal embryology

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