Signaling to chromatin through histone modifications

Article Abstract:

In identifying physiologically relevant targets of signal transduction pathways, research is conducted to understand signal-induced activation of transcription factors and components of the transcription machinery. Results reveal that these pathways directly act on the N-terminal tails of histones of chromatin components and, via covalent modifications they elicit appropriate responses.

Research, Cellular signal transduction

---

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation

Article Abstract:

Research has been conducted on the histone H3 Lys-9 methylation. The ability of this methylation to initiate and propagate X inactivation has been investigated and the results are reported.

Cell research, Cytological research, Methylation, X chromosome

---

Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II

Article Abstract:

Results show that the transcription cycle events are sequentially regulated by distinct forms of the yeast chromatin-remodeling enzyme, Isw1p. Data indicate that Isw1p exists in two distinct complexes, Isw1a and Isw1b, with the former functioning at promoters to repress genes, while the latter coordinating both transcription elongation and termination.

United Kingdom, Influence, Genetic aspects, RNA polymerases

Similar abstracts:

• Abstracts: Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
• Abstracts: The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Pausing for thought on the boundaries of imprinting
• Abstracts: Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
• Abstracts: Thermostable NADP(super +)-dependent medium-chain alcohol dehydrogenase from Acinetobacter sp. strain M-1: purification and characterization and gene expression in Escherichia coli
• Abstracts: The glococorticoid receptor inhibits NF-kappa-B by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.